I have fixed many large tanks in my day. Here are quick step by step instructions.
1.) Be sure the tank is leaking and it is not a canister filter or something else causing capillary action.
2.) How old is the tank? Look at the side edges of the tank. The area where the front glass meets the side piece of glass should be clear and free of air bubbles or "white" areas. If the sides are white, it would be prudent to re-seal the whole tank.
3.) Determin where the tank is leaking. If it is a side piece you are lucky. If it is the bottom. Get a case of beer before you start.
4.) If it is the side, the first thing you have to do is get the plastic frame off the tank. If it is an Oceanic tank this can be a real b**ch.
The best way to remove the frame is to take a putty knife and carefully work the putty knife up the outside of the frame and work it back and forth. DO NOT TRY TO PRY THE FRAME OFF. You stand the chance of cracking the tank. While you are doing this with the frams, keep "rocking" it back and forth with your hand.
5.) Once you get the frame loose, take a piece of furring strip or some type of wood and wedge it in to hold the frame away from the top and bottom of the glass side piece. Do this with the bottom frame as well. (putting the tank on a table with about 2' - 3' of it hanging over the edge helps)
A SHORT CUT: You can take a hacksaw and cut the frame piece in the corners on an angle and the remove just the side pieces.)
6.) Once you have the frames away from the side piece, Take a brand new single egde razorblade and work in into the seam from the outside. BE VERY CAREFUL, you still want to be able to pick your nose with your fingers when you are done. Do this starting at the top on both sides. You can cut away the interior silicone to help with this process. As you stick the single edged razor blade into the seam, use a pair of pliers to pull it out. Keep working the razor blade to whole way down both sides. With a tank this size, you can pull on the glass slightly to help it along.
7.) Once you have the sides loose, cut all of the excess silicone away on the bottom. Then slightly pull the piece of glass outward while running the razor blade on the inside. The side piece will eventually come loose.
8.) Take the side piece and using another single edge razor blade clean off all of the old silicone. Do the same for the front, back and bottom pieces. You can get the old silicone off with the razor blade. Some people will tell you, paint thinner, naptha, lighter fluid, alcohol (all types), etc. But none of these will "cut" the silicone. There is a silicone remover available from this company
http://www.rpm-technology.com/Digesil/Digesil.htm. I have never used it and I don't intend to start. Single edged razor blades work fine.
9.) Once all of the old silicone is removed you are now ready to re-seal the piece in place. This part will be the most controversial part of this whole dissertation. Go to an Ace Hardware and buy a tube of clear 100% silicone. It's like $5.99 for a caulking tube. This is 100% silicone, nothing else. I use at least 2 cases of this stuff a year. I buy it on sale for like $3.99 and keep it till I need it. There are literally 1,000's of different silicone sealants on the market that have all kinds of stuff in it for one reason or another. Again, this is 100% silcone. I don't give a rats a** what anyone tells you, this is fine to use.
10.) You should have some duct tape at this point as well. Put a medium size bead of silicone on the bottom and side of the tank. Once you have done this put a bead of silicone on the bottom of the side piece. Now sit it in place from the outside in. Move the top of the piece in so it is flush on the outside. Tape it securely at the top of each side with the duct tape. Now take your finger and go around the inside of the tank and smooth out the silicone. If it come out the outside of the tank that is great. Just leave it alone and let it dry. You can cut the excess off easier than you can clean in off. Now look at the front and back edges of the tank. Be sure there are no air bubbles. If there are, just take a glob of silicone and put it on your finger and push it out from the inside.
11.) Let the tank sit for at least 5 days so the silicone can cure.
IF IT IS THE BOTTOM THE TANK IS LEAKING FROM:
1. Take of the whole bottom frame.
2. If you are lucky the sides are siliconed to the base and the base isn't up inside the tank. If the bottom is up inside the tank, get two cases of beer.
3. This is a nightmare to fix. You just have to have lots of patience to cut it lose. Or you can clean off all of the silicone on the inside bottom of the tank, have a new piece of glass cut to size and silicone it in place over the old one. But this can be very expensive and it adds a tremendous amount of weight to your tank.
Take your time while doing this. And one last thing. You can not get away with just cleaning the silicone off the inside and putting new on. The way slicone works is in bonds together at the seams. Hence a clear looking seal is fine, a cloudy white seal is failing. If a seal is broken and you put new silicone on the interior, it will rip in a few months or even weeks. You can do this with 5 1/2's and 10's, but not a 180.
Hope this helps, Lonny